Monoclonal antibodies against CD47 (CD47 mAb) inhibit the interaction between SIRPα and CD47 effectively blocking the “don’t eat me” signal to activate TAMs and promote macrophage phagocytosis of, for example, of malignant osteosarcoma cells (87), and self-renewing leukemia stem cells (LSC) that promote AML (88). This evidence concerns the gene CD47 and osteosarcoma.