In renal cell carcinoma (RCC), analysis of iron metabolism genes, FPN, ferritin light and heavy chains, IRP2, and TfR1, revealed that these genes are all highly expressed in RCC, similar to other cancers, and TfR1 expression is used as a biomarker of RCC and is associated with worse survival outcomes (56). The gene discussed is IREB2; the disease is renal cell carcinoma.