When the CD4+ T cells from lupus mice were cultured with PD-L1 positive MDSCs from lupus and/or control mice, only PD-L1 positive MDSCs obtained from control mice markedly inhibited proinflammatory Th1, Th17 cells and reciprocally induced Foxp3+ Treg cells. The gene discussed is FOXP3; the disease is systemic lupus erythematosus.