CD274 and systemic lupus erythematosus: In the present study, we also verified that PD-L1 positive MDSCs more profoundly suppress lupus phenotype including the degree of proteinuria, serum levels of immunoglobulins, autoantibodies (anti-dsDNA IgG) and histopathologic findings of kidneys compared to PD-L1 negative MDSCs in two animal models of lupus (Roquin san/san mice and MRL/lpr mice) (Figures 3B, C and 4B–D).