HAVCR2 and Ehlers-Danlos syndrome, musculocontractural type: Moreover, an enrichment of the less functional CD56brightCD16−/low NK cells, expressing high levels of PD-1 (programmed cell death-1) and TIM3 (T cell immunoglobulin and mucin domain 3) exhaustion markers, has been found in advanced thyroid cancers, especially ATCs.