Post-translational modifications of specific mitochondrial proteins, such as ubiquitination of Myro2, increased SUMOylation of DRP1, decreased SUMOylation of mitofusins (MFN2), phosphorylation of DRP1, or alterations in their expression levels, such as excessive increase or deficiency of PGC1-alpha, increased levels of DRP1, reduced expression of MFN2 or OPA-1, leads to several heart diseases (Fan et al., 2020). This evidence concerns the gene MFN2 and heart disorder.