PANX1 and brain ischemia: In the study of cerebral ischemia and anoxia injury, Thompson et al. also found that the Panx1 channel played an important role in cerebral ischemia and anoxia injury by regulating the transmission of intracellular and extracellular Ca2+ and ATP, and inducing neurocytes apoptosis and inflammatory response through various signal pathways (Thompson et al., 2006).