It has been previously reported that RA counteracts UVA-related impairment in murine melanoma cells (Sanchez-Campillo et al., 2009), inhibits IFN-γ-induced inflammation in primary human keratinocytes (Georgiev et al., 2012), protects human fibroblasts from the damage caused by parabens (Matwiejczuk et al., 2020) and stimulates collagen biosynthesis (Chaiyana et al., 2019; Matwiejczuk et al., 2020). The gene discussed is IFNG; the disease is melanoma.