Since CF is a multi-organ disorder which does not exclusively affect epithelia but also for example innate immune and endothelial cells (reviewed in (Declercq et al., 2019; Lara-Reyna et al., 2020), respectively), cells from many different organs can be used to understand the diverse CFTR-associated phenotypes and study a correction by rescue strategies. This evidence concerns the gene CFTR and cystic fibrosis.