MTOR and cyst: For example, mTOR inhibitors (everolimus and sirolimus), metformin (an agonist of AMPK), 2-deoxy glucose (2DG) (a glucose analog that can paralyze the glycolytic pathway), tyrosine kinase inhibitors (bosutinib and tesevatinib) and caloric restriction diet are all reported to retard cyst growth in ADPKD patients to different extent (Testa and Magistroni, 2020).