NFKB1 and autosomal dominant polycystic kidney disease: In Cy/+ Han:SPRD rat, which is a non-orthologous rat model of ADPKD, FTY720 downregulated the expression of proinflammatory cytokines including IL-6 and TNFα, and attenuated the activation of inflammatory pathways such as the STAT and NF-κB pathways, leading to the inhibition of renal cyst growth and improvement of renal function.