In an orthologous mouse model of human ADPKD (Pkd1flox/flox;Pkhd1-Cre), stevioside and steviol inhibited the CFTR expression and mTOR/S6K proteins by activating AMP-activated protein kinase, thereby delaying the cyst development through inhibiting proliferation of renal epithelial cells (Yuajit et al., 2014). This evidence concerns the gene MTOR and cyst.