Tumor uptake of 89Zr-Cbl (Figure 1) in HER2-positive MDA-MB-453 xenograft models was 3.8 ± 0.77% ID/g with T/B ratio of about 9.7 at 48 h p. i. In addition, clearance from blood was evident from 4 to 48 h with approximately 90% decrease in activity concentration by 48 h p. i. A drawback of this radiotracer is its high uptake in the kidney. Here, ERBB2 is linked to neoplasm.