As shown in Figure 5B, compared with the sham rats, muscle IGF-1 mRNA reduced in the 5/6 nephrectomized rats, interestingly, which was inhibited by YQJPXYXZ; KT supplementation tended to increase the level of skeletal muscle IGF-1 mRNA, but no statistical difference was observed compared with the CKD and YQJPXYXZ groups. Here, IGF1 is linked to chronic kidney disease.