In accordance with previous results, EF and FS decreased significantly, while LVIDs, LVIDd and BNP increased abnormally in the doxorubicin-induced heart failure animal model group, (Hang et al., 2017; Wen et al., 2019) indicating that there was serious cardiac damage and left ventricular dilatation, that is, the cardiac pumping function decreased. This evidence concerns the gene NPPB and heart failure.