FGF1 and hydrops fetalis: To sum up, this research offered evidence in vivo, which intensely suggested that the combined use of aFGF targeted mediated by novel nanoparticles-microbubble complex combined with UTMD could effectively antagonize cardiac damage induced by DOX and protect left ventricular cardiac function in DOX-HF rats, and its mechanism may be related to anti-oxidation, anti-fibrosis, anti-apoptosis and cardiac angiogenesis (Figure 7).