After the intervention of aFGF-NP + CPMBs combined with UTMD, the expression of Bcl-2 protein increased significantly, while the expression of Bax protein decreased significantly, suggesting that the cardiac-protective effect of aFGF-NP + CPMBs combined with UTMD on doxorubicin-induced heart failure is related to its anti-apoptosis characteristics. Here, BAX is linked to heart failure.