In accordance with previous results, EF and FS decreased significantly, while LVIDs, LVIDd and BNP increased abnormally in the doxorubicin-induced heart failure animal model group, (Hang et al., 2017; Wen et al., 2019) indicating that there was serious cardiac damage and left ventricular dilatation, that is, the cardiac pumping function decreased. The gene discussed is NPPB; the disease is Left ventricular dilatation.