TRPM2 and neoplasm: In addition, about the treatment of targeting TRPM2-AS and WEE1 in RB, we think targeting TRPM2-AS may be more effective because TRPM2-AS can negatively regulate miR-497 expression, which also targets vascular endothelial growth factor A, a gene closely related to cell proliferation, migration, invasion, and tumor angiogenesis (Li et al., 2017a), except for WEE1 in RB.