For example, the hypothesis that tau undergoes an abnormal redistribution or mislocalization from the axon to the somatodendritic compartment is often discussed as a key pathological step in tauopathies such as Alzheimer’s disease (Ittner and Götz, 2011; Zempel and Mandelkow, 2014). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.