SHANK2 and attention deficit-hyperactivity disorder: The involvement of SHANK genes in NMDA and AMPA glutamate receptors, which are important in defining synaptic plasticity and cognitive functioning (Guilmatre et al., 2014; Monteiro and Feng, 2017), suggests that SHANK genes may play a crucial role in memory and executive dysfunctions found in a wide range of neuropsychiatric disorders, including ADHD and ASD.