However, even recent large ASD GWAS studies also failed to identify SHANK genes (The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, 2017; Grove et al., 2019), despite the fairly well-replicated association of SHANK genes with ASD in previous association and animal studies, cited above (Peça et al., 2011; Won et al., 2012; Leblond et al., 2014; Connolly et al., 2017). Here, SHANK2 is linked to autism spectrum disorder.