Nevertheless, the large NHS II study did not reveal any significant associations between endometriosis and adiponectin (RR 0.8, 95% CI 0.5–1.2, p 0.48) or leptin-to-adiponectin ratio (RR 0.8, 95% CI 0.4–1.4, p 0.14) after adjustment for BMI [60]. The gene discussed is LEP; the disease is endometriosis.