Multivariate analysis of association between the two SNPs and AD risk adjusted for age, sex, and APOEε4 positivity as potential confounding variables revealed no changes in comparison with the univariate analysis (p > 0.05, OR = 0.85-1.32 for MMP2, Table 2; p > 0.05, OR = 0.98-1.06 for MMP3, Table 3). The gene discussed is MMP3; the disease is Alzheimer disease.