In this study, we examined the level of expression of plasma biomarkers of inflammation (TNFa and its receptor [TNF-R1], IL-6 and its receptor [sIL-6R], CCL5, IL-8, IL-1b, TIMP-1) and NFL (highly informative of neuronal alteration), in 40 AD patients of Cytocogma cohort32, half of whom were considered to be slow decliner and half fast decliners (based on variation in MMSE over time). This evidence concerns the gene NEFL and Alzheimer disease.