In the present work, we evaluated the potential informativity of peripheral inflammation in AD: our study aims to describe the potential association between plasma NFL level, peripheral inflammation (through quantification of IL-1β, IL-6, TNFα, CCL5, TNF-R1, sIL-6R, TIMP-1, IL-8 in blood) and cognitive decline (assessed by the MMSE and ADAScog scales), through a 2-year follow-up of 40 AD patients from the Cytocogma cohort (CHU of Poitiers, Pr M. Paccalin). This evidence concerns the gene IL6R and Mental deterioration.