The blue and yellow modules (Fig. 4) harbor HH genes positively associated with pathophysiological mechanisms in epilepsy—such as vascular remodeling (ITGB8, UCQRB), glutamatergic excitatory system (TANC2, SCLC25A18) and reactive gliosis (SPOCK1)-and with putative compensatory mechanisms linked to hippocampal neuron survival (KIF1B, YAP1). The gene discussed is ITGB8; the disease is epilepsy.