SCN1A and Febrile seizure (within the age range of 3 months to 6 years): Interestingly, epilepsy, hippocampal sclerosis, and febrile seizures are linked by common genetic variation around SCN1A71, The downregulation of SCN1A was also reported as an epilepsy biomarker by Guelfi et al.20, who studied the transcriptome of cortical tissue samples from 86 RMTLE patients.