The blue and yellow modules (Fig. 4) harbor HH genes positively associated with pathophysiological mechanisms in epilepsy—such as vascular remodeling (ITGB8, UCQRB), glutamatergic excitatory system (TANC2, SCLC25A18) and reactive gliosis (SPOCK1)-and with putative compensatory mechanisms linked to hippocampal neuron survival (KIF1B, YAP1). Here, SPOCK1 is linked to epilepsy.