SLC6A4 and Anxiety: This in combination with the fact that SERT has a lower binding capacity in the spring and summer and that treatment with an antidepressant further blocks the SERT, might contribute to a higher risk for suicide in the elderly in periods of higher temperature and more sunshine, through a redundancy of serotonin in the synaptic cleft leading to an over-activated state with anxiety and psychomotor agitation.