Though it is worth noting that despite the fact that tau corelates quite well with cognitive decline in diseases such as Alzheimer’s, there is few convincing reports of tau induced cell death in ex vivo or in vitro model systems, suggesting other mechanisms/stressors may be required and accumulation of insoluble phosphorylated tau on its own is not sufficient to induce cell death. The gene discussed is MAPT; the disease is Mental deterioration.