These include 15 hotspots with above-median z-scores, hereof a single TP53 splice-site hotspot with a high z-score, and among others, two hotspots in the 5’ UTRs of TP53 and NUP214, a hotspot in an enhancer for EGFR, and a hotspot in the 3’ UTR for CTNNA2. We describe the few gene regulatory SNV and indel hotspots associated with cancer genes with an above-median z-score (marked with * in Fig. 4) later or in the Supplementary Note. The gene discussed is TP53; the disease is cancer.