Interestingly we also saw an enrichment of cancer genes among SNV enhancer hotspots, which was partly caused by a potential driver hotspot in an enhancer for POU2AF1. Amplification of POU2AF1 has previously been shown to promote cancer development in multiple myeloma45, and a germline variant in the 3’ UTR of POU2AF1 has recently been associated with susceptibility to lymphoma46. Here, POU2AF1 is linked to cancer.