VCAM1 and hypertensive disorder: The induction of VCAM1 expression in the heart and kidney of 5/6Nx mice was not affected by the administration of retinol (Supplementary Fig. 12d) or dietary deficiency of vitamin A (Supplementary Fig. 17b), suggesting that the induction of adhesion molecules was not due to changes in the retinol levels, but instead due to high blood pressure and RAAS activation81,82.