hRNase 1 induced phosphorylation of EphA4, but not of EphA3 or EphA5 (Supplementary Fig. 7b), and activation of phospholipase C-γ (PLCγ), a downstream signaling molecule of EphA430, in BT-549 basal-like breast cancer cells (Supplementary Fig. 7c). This evidence concerns the gene EPHA3 and breast cancer.