It is worthwhile to note that, in addition to hRNase 1, hyperglycosylation of RNase proteins in cancer cell lines was also observed in human RNase 2 in promyelocytic leukemia cells; treatment of PNGase F glycosidase resulted in a change of RNase 2 from a heterogeneous to a homogenous pattern, in terms of molecular weight from ~22–45 kDa reduced to ~15 kDa, respectively72. The gene discussed is RNASE2; the disease is acute promyelocytic leukemia.