HDACs and HSP90 are involved in the activation of several oncogenic pathways in cancer maintenance, including the PI3K/AKT/mTOR, STAT, EGFR, and RAF/MEK/ERK pathways, which were also highly enriched in AML and ALL patient profiles (Supplementary Fig. 3C). The gene discussed is AKT1; the disease is acute lymphoblastic leukemia.