DGKE and Renal insufficiency: Unlike the constitutive Dgke-knockout mice that do not have spontaneous phenotype, endothelial specific Tie2CreDgkefl/fl conditional knockout mice developed occlusion of the glomerular capillaries (Figure 2, D and E), schistocytosis (Figure 2, F and G, and Supplemental Figure 4A), hemolytic anemia (Figure 2H and Supplemental Figure 4B), thrombocytopenia (Figure 2I), and renal insufficiency as early as 2 months of age (Figure 2J).