As observed in Tie2CreDgkefl/fl mice treated with the PTEN inhibitor, Tie2CreDgkefl/fl Cox2-COE mice did not develop glomerular capillary occlusion (Figure 4, A and B), schistocytosis and hemolytic anemia (Figure 4, C–E, and Supplemental Figure 4D), thrombocytopenia (Figure 4F), and renal insufficiency and proteinuria (Figure 4, G and H). The gene discussed is PTGS2; the disease is Renal insufficiency.