In addition, CD109 silencing completely inhibited the growth of the MES-like BT13 tumors that consist of a large primary tumor (Figure 5, B, F, H, and J) as well as the growth of the PN-like BT18 and ZH305 models that grow very diffusively (Figure 5, C, D, and K–N). The gene discussed is CD109; the disease is neoplasm.