In osteosarcoma, the intrinsically highly expressed YY1 can bind to CBP, which in turn binds to c-Myc to downregulate YY1 acetylation and jointly decrease the transcriptional activity of the promoter of the integrin α3 subunit, thus promoting the malignant phenotype of osteosarcoma cells [82]. Here, MYC is linked to osteosarcoma.