Again, many of the immune-modulatory genes differentially expressed in the mouse model were site-specifically recapitulated, e.g., higher CCL2, CXCL5, CXCL9, CXCL11, CXCL14, CXCL17, and IDO1 in lung cancers and higher CXCL12, FGL1, and LAG3 in liver cancers (Fig. 6a). This evidence concerns the gene IDO1 and lung cancer.