After adjusting for confounding variables (age, sex, sport modality, BMI and nutritional follow-up), the TNF-α TCA haplotype was associated with increased tendinopathies risk, either considering all cases (P = 0.006), patellar (P = 0.004), rotator cuff (P = 0.008) or Achilles tendinopathies (P = 0.03) (Table 3). Here, TNF is linked to disease of the tendon.