In details of CNVs of some genes in the MEmagenta module, it was found that the CNVs (amplification) and expression of SKA3 and RUVBL1, which promoted tumor metastasis and played a role in the development of stem cells [37–40], were all increased with the Gleason grade (Additional file 7: Fig. S3a. Here, RUVBL1 is linked to neoplasm.