In addition, this study supported that knockdown of KIF15 promote apoptosis of BL cells, accompanied by decreased expression of pro-protein BID, Caspase3, Caspase8, HTRA, IGFBP-6, p53, SMAC, sTNF-R1 and TNF-β, while increasing the expression of anti-protein Bcl-2. The gene discussed is IGFBP6; the disease is Burkitt lymphoma.