PIK3CA and Burkitt lymphoma: Moreover, we estimated that KIF15 is involved in BL cell activity through increasing expression of pro-apoptosis proteins, such as Caspase3, Caspase8, HTRA, IGFBP-6, p53, SMAC, sTNF-R1 and TNF-β, meanwhile decreasing expression of anti-apoptosis proteins Bcl-2, and regulating downstream pathways, such as p-Akt, CCND1, CDK6 and PIK3CA.