In a recent study from Augsburg, Germany, investigating the relevance of biomarker-defined pathways for the development of DM, and also for coronary heart disease, many associations, such as cytokines, endothelial dysfunction, hemostasis, hormone regulation, tissue remodeling, and others, showed similar strength for DM and CHD, but the insulin-like growth factor binding protein 2 explained DM risk best [10]. Here, IGFBP2 is linked to endothelial dysfunction.