We reported in cohorts of type 1 and type 2 diabetes that baseline plasma copeptin was significantly associated with LLA (adjusted HR 1.89 (1.28–2.82), p = 0.002 in type 1 diabetes and 1.42 (1.15–1.74), p = 0.001 in type 2 diabetes) [9]. The gene discussed is AVP; the disease is type 2 diabetes mellitus.