One explanation for the link between TP53 rs1625895 and the increased risk of sarcopenia related obesity in our study is that mutation in TP53 rs1625895 like p53 rs1042522 results in impaired function of TP53 as a negative regulator of adipogenesis, however the exact mechanism is unclear. Here, TP53 is linked to obesity due to melanocortin 4 receptor deficiency.