In aprevious study investigating the effects of SET on endothelium-derived inflammatorymarkers and walking capacity in patients with IC, a significant increase in walkingcapacity and a significant reduction in E-selectin and ICAM-1 were observed after 8 weeks.10 The results from the present study indicate that INP treatment of one legdoes not affect the total vascular inflammatory burden caused by atherosclerosis, incontrast to what is observed after a period with SET in patients with IC. The gene discussed is SELE; the disease is atherosclerosis.