To examine if blood cancer EVs could increase MMP9 and IL-6 secretion in monocytes, THP-1 cells were treated with either HG3, I83, K562 and U266 EVs for 24 h and the levels of MMP9 and IL-6 in the THP-1 conditioned media was determined. This evidence concerns the gene IL6 and hematopoietic and lymphoid system neoplasm.