Multivariate analyses adjusted for sex, age, PS, creatinine clearance, and hepatic and lymph node metastases confirmed statistically significant correlations with OS and PFS for the SII + PD-L1 and SII + PD-L1 + LDH combinations, independently of other covariates (Supplementary Table S1, available at https://doi.org/10.1016/j.esmoop.2021.100118). This evidence concerns the gene CD274 and metastatic malignant neoplasm in the lymph nodes.