Our results on SII and NLR confirm the role of tumor inflammation in advanced UC, as reported for other tumors such as the non-small-cell lung cancer.15, 16, 17,33 In other solid tumors, a high SII has been reported to be an independent negative prognostic factor34, 35, 36 and NLR has been combined with PD-L1 and/or LDH.33 Here, CD274 is linked to neoplasm.