CRH stimulates cutaneous production of cytokines like IL-6 and IL-11 and amplifies expression of adhesion molecules and production of transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), shifting keratinocytes into an immune active state.16 CRH receptors are increased in psoriasis compared to normal skin, and expression of CRH-R1 (CRH receptor type 1) is correlated with PASI.18 The gene discussed is NFKB1; the disease is psoriasis.