We included new findings on neurotrophic theory for stress-related mood disorders [12,13], additional genetic and neurobiological factors such as GPR50 polymorphisms [14], associations of depression with morphometric brain-changes [15], and results of previous reviews that included cross-sectional studies [11] in our framework–the diathesis-stress model for mental disorders (see Fig 1). This evidence concerns the gene GPR50 and mood disorder.