Specifically, we found that Vegfa gene expression is 1.56-fold up-regulated in non-pigmented, as compared to pigmented mouse melanocytes (Student’s t-test P = 6.58 x 10−3), and 5.12-fold up-regulated in non-pigmented, relative to pigmented, mouse melanoma cells (Student’s t-test P = 1.43 x 10−6, Fig 7A). This evidence concerns the gene VEGFA and melanoma.