Moreover, Apoe levels were 235.56-fold up-regulated in pigmented mouse melanocytes, as compared to their non-pigmented counterparts (Student’s t-test P = 8.61 x 10−3), and 5.05-fold up-regulated in pigmented versus non-pigmented mouse melanoma cells (Student’s t-test P = 1.79 x 10−2; Fig 7B). This evidence concerns the gene APOE and melanoma.