We also observed evidence that rs10168523 was an islet eQTL for SIX3 and SIX2 (SIX3 P = 5.1x10-23, SIX2 P = 8.2x10-10; Fig 4G), where the T2D risk allele was correlated with reduced expression of both genes. This evidence concerns the gene SIX3 and type 2 diabetes mellitus.