Considering the expression of DDR‐related transcripts in relation to the clinical variables grouped as: L‐sarcomas vs non‐L‐sarcomas and grade 3 vs grade 1–2, the outcome was as follows: of 118 genes analyzed, only two genes were significantly overexpressed (i.e., BRIP1, DNAJB5) in L‐sarcomas, compared with non‐L‐sarcomas, whereas 16 genes were significantly underexpressed (i.e., DDB2, DNAJA1, DNAJA2, DNAJB2, DNAJC10, DNAJC14, DNAJC16, ERCC3, ERCC6, MMS19, MSH2, PMS2, SMUG1, TDG, and XRCC5) in L‐sarcomas, compared with other STS subtypes. This evidence concerns the gene ERCC6 and telomere syndrome.