First, a G>C missense variant at chr7:44,806,821 in lipoxygenase homology domains 1 (LOXHD1), a gene that is known to cause hearing loss in humans and mice (Grillet et al. 2009), was predicted to result in a glycine-to-alanine substitution (Fig. 2). Here, LOXHD1 is linked to hearing loss disorder.