In addition to nonsyndromic hearing loss, an enrichment of LOXHD1 variants in patients affected by Fuchs endothelial corneal dystrophy (FECD) has been observed in one study, suggesting that LOXHD1 could be relevant to the FECD pathogenesis (Riazuddin et al. 2012). Here, LOXHD1 is linked to hearing loss disorder.