LOXHD1 and Fuchs endothelial corneal dystrophy: In addition to nonsyndromic hearing loss, an enrichment of LOXHD1 variants in patients affected by Fuchs endothelial corneal dystrophy (FECD) has been observed in one study, suggesting that LOXHD1 could be relevant to the FECD pathogenesis (Riazuddin et al. 2012).