LOXHD1 and hippocampal atrophy: As MROH8 has been associated with red blood cell volume, body mass index, telomere length and hippocampal atrophy in humans (Buniello et al. 2019) and its predicted impact was less pathogenic, making it an unlikely candidate variant, we focused on LOXHD1. The chr7:44,806,821G>C variant is predicted to cause a glycine-to-alanine substitution p.(G1914A) in the fourteenth PLAT domain of the canine LOXHD1 protein (Fig. 2c).