Univariate analysis in all 537 patients allocated chemotherapy identified the following baseline factors associated with worse OTU (P ≤ .05): distant metastases, raised B-type natriuretic peptide (BNP) or N-terminal prohormone of brain natriuretic peptide (NT-proBNP), leukocytosis, raised neutrophil to lymphocyte ratio (NLR), hypoalbuminaemia, raised urea, severe frailty (dementia, activities of daily living [ADL], and polypharmacy domains), poor global QL, and impaired taste (eFigure 1 in Supplement 3). The gene discussed is NPPB; the disease is Hypoalbuminemia.