ARID1A and familial pancreatic carcinoma: In pancreatic cancer, recent studies have shown that ARID1A is necessary to maintain terminal differentiation of pancreatic acinar cells, and knockout of ARID1A results in the accelerated formation of acinar-to-ductal metaplasia (ADM) and then pancreatic intraepithelial neoplasia (PanIN) lesions (Zhang, 2018; Livshits et al., 2018; Wang et al., 2019).