PLAU and neoplasm: Interestingly, IPA analysis performed in our data showed “Invasion of tumor” as one of the pathways affected by aging; some of the dysregulated genes were AREG, BIRC5, CCL2, CD14, CTSB, FN1, HMOX1, IL6, MMP14, MMP3, PLAU, S100A8, SERPINE1, SPP1, THBS1, VCAN.