Moreover, A172-exo and U373-exo inhibited the apoptosis of glioma cells relative to the control cells (Figure 2A), which was consistent with findings that the protein expression of Bcl-2 was increased while the levels of cleaved-caspase3 and cleaved-caspase9 were decreased in cells treated with exosomes (Figure 2B). This evidence concerns the gene BCL2 and central nervous system cancer.