The present study consistently showed that suppression of oxidative stress induced by Nrf2 signalling activation restrained p65 phosphorylation and pro‐inflammatory cytokine production, reflecting that anti‐oxidative capacity of wogonin could also attenuate liver injury by suppressing NF‐κB signalling pathway, which suggests that the manipulation of anti‐oxidative stress machinery could be referred as alternative strategy for sepsis and other inflammation‐associated disorders. Here, NFKB1 is linked to Sepsis.