In the present study, we initially proved that wogonin treatment could improve the survival of mice with LPS‐ or CLP‐induced sepsis, accompanied with the rescue of reduced body temperature and respiratory rate, and the suppression of pro‐inflammatory cytokines TNF‐α, IL‐1β, IFN‐γ and IL‐6 in circulation. This evidence concerns the gene IFNG and Sepsis.