Remarkably, as shown in Fig. 4, BMP4, PHLDA1, and GJB5 expression levels were significantly upregulated in the G12A-, G12D-, G12V- transfected cells, compared those in the WT-transfected cells, suggesting that these genes can be added to the list of candidates of KRAS G12A, G12D, or G12V target genes in CRC. The gene discussed is GJB5; the disease is colorectal carcinoma.