On the other hand, somatic mutations in BRAF (61/534, 11.4%), PIK3CG (27/534, 5.1%), PIK3CD (16/534, 3.0%), and NRAS (22/534, 4.1%) were frequently detected in KRAS wild-type CRC compared to KRAS-mutated CRC. Here, PIK3CD is linked to colorectal carcinoma.