Of the known downstream genes in the KRAS pathway, increased expression was observed for CCND1, DUSP2, DUSP4, ETS2, JUN, RAC2, RAC3, SPRY4, ELK1, RALGDS, and RASAL1 in KRAS mutated CRC (Fig. 2). The gene discussed is RASAL1; the disease is colorectal carcinoma.