TIE1 and diabetes mellitus: Although we observed severe fibrosis in the diabetic kidneys of SIRT3-deficient mice (belonging to the C57BL/6 background), the study of fibrogenic phenotype in overexpression mice (Tie1+SIRT3 tg, of C57BL/6 background) was limited because the diabetic kidneys of C57BL/6 mice show limited fibrogenesis upon diabetes induction.